Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | The frequencies of HD genotype of H63D mutation were significantly increased in HCC patients compared to control group and to cirrhosis group. | 21925577 | 2011 |
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0.090 | GeneticVariation | BEFREE | Similarly, hepatitis C patients with H63D homozygosity had a higher likelihood of cirrhosis compared with those with H63D wild type (OR: 2.35, CI : 0.19-28.5, P = 0.52). | 15780041 | 2005 |
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0.090 | GeneticVariation | BEFREE | C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis. | 12865278 | 2003 |
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0.090 | GeneticVariation | BEFREE | By multivariate logistic regression analysis the odds ratio for the development of advanced fibrosis or cirrhosis (F2-F4) was 2.5 for HCV-infected patients carrying a heterozygous C282Y mutation and 4.8 for HCV-infected patients with C282Y/H63D and C282Y/S65C compound heterozygosity. | 14557859 | 2003 |
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0.090 | GeneticVariation | BEFREE | C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals. | 12586300 | 2003 |
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0.090 | GeneticVariation | BEFREE | HFE mutations (C282Y and H63D) were assessed in 162 consecutive patients (131 men/31 women) with HCC.A total of 159 patients had cirrhosis. | 12591066 | 2003 |
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0.090 | GeneticVariation | BEFREE | The aim of this study was to investigate the association between HFE gene mutations (C282Y, H63D) and hepatocellular carcinoma in patients with alcoholic and virus-related cirrhosis. | 12003382 | 2002 |
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0.090 | GeneticVariation | BEFREE | The possibility of cirrhosis-associated hemosiderosis secondary to an iron metabolism abnormality associated with the H63D mutation of the HFE gene is proposed. | 11473464 | 2001 |
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0.090 | GeneticVariation | BEFREE | The aims of this study were to define the prevalence of the mutations 845G --> A and 187C --> G (C282Y and H63D) in the HFE gene associated with hereditary hemochromatosis in Italian patients with hepatocellular carcinoma occurring in cirrhosis and to analyze the interaction between these mutations and other established risk factors for hepatocellular carcinoma. | 11500061 | 2001 |